[Machine Translation] A masterpiece depicting the agony and hope for the coming modern nation at the end of the turbulent Edo period! Manjiro Imutani, a samurai, and Ryoan Tezuka, a doctor, fulfilled their missions while being tossed about by the currents of the times. This moving romance at the end of the Tokugawa Shogunate depicts the lives of these two men, while mixing in the author's own roots, up to the dawn of the modern nation! In the fifth volume, the smallpox station burns down. This has made Ryosen feel quite vulnerable. Also, the movement to overthrow the shogunate becomes active, and Ii Oro is assassinated. Also, cholera arrives in Japan, and Ryozen's mother dies after contracting the disease. Synopsis Manjiro is temporarily imprisoned for the overthrow of the shogunate, but thanks to the wisdom of Ryoan and others, he is able to escape from prison without incident. He is sheltered in the house of his friend Tetsutaro, where he learns of the corruption of the Grand Elder Ii. When Manjiro raises his voice to ask if there is any way to expose the corruption of the Ooer, Hoya, a government official, tells Manjiro to hand over the evidence of corruption to Yasushima of the Mito clan, who is against the Ooer. Manjiro travels to Mito and meets with Yasujima. The night before, Manjiro meets Takahashi of the Mito clan, who asks Manjiro to join him in assassinating Ii. ...... ( Episode 5 ). The birth of Ryoan's wife, Otsune, has begun. The baby was growing so large that a caesarean section had to be performed. Just as the surgery was about to begin, word came that the smallpox clinic Ryosen had painstakingly established was about to be completely destroyed by a fire from the fold. Ryosen was so distraught by this news that he could no longer perform the surgery on Otsune ( ep. 6 ). Characters Manjiro Ibuya (a samurai of the Fuchu Clan, but left the clan and became a ronin. He is gifted with a sword), Tezuka Ryoan (son of a doctor, Tezuka Ryosen. Heisuke (Ryoan's father, a Dutch doctor), Ryoan's wife Otsune (episodes 1 and 6), Yukichi Fukuzawa (episode 6), Doshin Hoya (episodes 2-4), Denkichi Meakashi (episodes 2-4), Tetsutaro Yamaoka (episode 4), Tohei Ushikubo (episode 6), Manjiro's mother (episode 4), Ryoan's mother ( ep 1 )